Disparities in growth and access to resources among regions and cities call for a localised policy support, which customises innovative solutions to specific needs and capacities. Innovation in the broader sense can enable the achievement of concrete results in fighting territorial inequalities if the underlying approaches integrate both "leave-no-one-behind" and "leave-no-place-behind" statements into combinations of relevant actions and partnerships at the appropriate territorial level. This debate will combine perspectives from diverse stakeholders on issues such as: Are territorial inequalities expected to exacerbate in the future? What challenges are countries and cities facing in addressing them? What opportunities come with technologies, new governance models and social innovations?